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This manuscript characterizes the first model of socially transferred pain in which mice housed in the same room as mice subjected to inflammatory- or drug withdrawal-induced pain develop congruent hyperalgesia. This pain is communicated via olfactory cues. This model provides 3 For the pain field, we show that pain can be induced solely by social factors without prior tissue damage. For the alcohol field, we demonstrate alcohol dependence following drinking in a mouse. For studies using animal models, we show that housing control in the same room as experimental animals may not be appropriate due to the possibility of social transfer of physiological states


Smith, M.L., Hostetler, C., Heinricher, M.M. & Ryabinin, A.E. (2016) Social Transfer of Pain in Mice. Science Advances, 2016:2 e1600855 

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